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The purpose of this study is to assess the safety and tolerability of clenbuterol (taken by mouth) in subjects with ALS (amyotrophic lateral sclerosis) and to assess the effectiveness of clenbuterol with regard to motor function in subjects with ALS. Subjects will be in this study approximately 24 weeks. Analysis Population Description Intention to treat analyses were performed for 20 participants who had at least one ALSFRS-R measurement post-treatment. These calculations for ALSFRS-R were based on the 11 patients who completed all 6 months on some dose of the drug, e. This invention provides a novel repurpose of the beta-2 adrenomimetic clenbuterol for use in ALS patients. Advantages This therapy has already been used in asthma patients as a bronchodilator and has shown efficacy in other muscle conditions such as Pompe disease. I saw on another website that they just posted the Duke University Clenbuterol trial result summary page from the small study overseen by Dr. For ALS: Adults—50 milligrams (mg) (10 milliliters [mL]) 2 times a day (every 12 hours). Children—Use and dose must be determined by your doctor. If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Amyotrophic lateral sclerosis (ALS) is a progressive, neurodegenerative, and inevitably fatal disease associated with loss of upper and lower motor neurons. 1 There is no cure for ALS, life expectancy is typically 2–5 years after symptom onset, and the only approved drug, riluzole, has a modest effect on survival


The purpose of this study is to assess the safety and tolerability of clenbuterol (taken by mouth) in subjects with ALS (amyotrophic lateral sclerosis) and to assess the effectiveness of clenbuterol with regard to motor function in subjects with ALS. Subjects will be in this study approximately 24 weeks. Clenbuterol is a substance that has steroid-like effects and is classified as a beta2-adrenergic agonist. This means that it stimulates the beta2-adrenergic receptors in your throat. Affiliation 1 Department of Neurosciences, Neurology Unit, Piove di Sacco Hospital, Padova, Italy. The study drug, clenbuterol, is taken twice a day. The anabolic effects of clenbuterol have been recognized for a long time. Clenbuterol augments the expression of specific muscle proteins with a differential effect on type I and type II fibres. Furthermore, clenbuterol induces the synthesis of endogenous nerve growth factor (NGF) and may itself. This is an open label pilot trial in which 25 people with ALS will take clenbuterol orally at 40-80 micrograms twice daily for 24 weeks. Drug: Clenbuterol The intervention is treatment with oral clenbuterol at 40-80 micrograms twice daily for 24 weeks moraldehornuez.com/d-bal-by-crazybulk-clenbuterol-side-effects-heart/


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